| UNIVERSITY COLLEGE OF THE GOLD COAST | ||
| David Mowbray Balme | 1948-1957 | Principal |
| UNIVERSITY COLLEGE OF GHANA | ||
| David Mowbray Balme | 1957-1958 | Principal |
| Raymond Henry Stoughton | 1958-1961 | Principal |
| UNIVERSITY OF GHANA | ||
| Conor Cruise O'Brien | 1962-1965 | Vice-Chancellor |
| Alexander Adum Kwapong | 1966-1975 | Vice-Chancellor |
| Daniel Adzei Bekoe | 1976-1983 | Vice-Chancellor |
| Akilagpa Sawyerr | 1985-1992 | Vice-Chancellor |
| George Benneh | 1992-1996 | Vice-Chancellor |
| Ivan Addae-Mensah | 1996-2002 | Vice-Chancellor |
| Kwadwo Asenso-Okyere | 2002-2006 | Vice-Chancellor |
| Clifford Nii-Boi Tagoe | 2006-2010 | Vice-Chancellor |
| Ernest Aryeetey | 2010-2016 | Vice-Chancellor |
| Ebenezer Oduro Owusu | 2016-2021 | Vice-Chancellor |
